The domain within your query sequence starts at position 248 and ends at position 406; the E-value for the 1io0 domain shown below is 9e-46.

NQTDLDGSLRRVRQNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADE
SVAFALANMLRENRSVTTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHA
EMEISRLLKANTTLLKMGYHFELPGPRMVVTNLLTRNQD

This is a PDB domain - please see the PDBSUM entry of 1io0 for further annotation