The domain within your query sequence starts at position 248 and ends at position 406; the E-value for the 1io0 domain shown below is 9e-46.
NQTDLDGSLRRVRQNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADE SVAFALANMLRENRSVTTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHA EMEISRLLKANTTLLKMGYHFELPGPRMVVTNLLTRNQD